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Did you mean SLC22A12 end renal insufficiency (1 results)?
The SLC22 Transporter Family: A Paradigm for the Impact of Drug Transporters on Metabolic Pathways, Signaling, and Disease.
Nigam SK. Nigam SK. Annu Rev Pharmacol Toxicol. 2018 Jan 6;58:663-687. doi: 10.1146/annurev-pharmtox-010617-052713. Annu Rev Pharmacol Toxicol. 2018. PMID: 29309257 Free PMC article. Review.
., gut microbiome products, bile acids, tricarboxylic acid cycle intermediates, dietary flavonoids and other nutrients, prostaglandins, vitamins, short-chain fatty acids, urate, and ergothioneine), as well as uremic toxins associated with chronic kidney disease. Certain SLC22 tra …
., gut microbiome products, bile acids, tricarboxylic acid cycle intermediates, dietary flavonoids and other nutrients, prostaglandins, vita …
Uric acid and the kidney: urate transport, stone disease and progressive renal failure.
Capasso G, Jaeger P, Robertson WG, Unwin RJ. Capasso G, et al. Curr Pharm Des. 2005;11(32):4153-9. doi: 10.2174/138161205774913219. Curr Pharm Des. 2005. PMID: 16375737 Review.
In this brief review and update, we try to cover recent developments in our understanding of uric acid transport by the kidney, the contribution of uric acid to renal stone disease, its potential role in progressive renal failure and, most recently, the novel and as …
In this brief review and update, we try to cover recent developments in our understanding of uric acid transport by the kidney, the contribu …
Genotype and Phenotype of Renal Hypouricemia: A Single-Center Study from China.
Mou L, Zhu L, Chen X, Hu Y, Zhu H, Xu Y. Mou L, et al. Mol Diagn Ther. 2024 Jan;28(1):87-99. doi: 10.1007/s40291-023-00683-w. Epub 2023 Nov 16. Mol Diagn Ther. 2024. PMID: 37971623
BACKGROUND: Renal hypouricemia (RHUC), a rare inherited disorder characterized by impaired uric acid reabsorption and subsequent profound hypouricemia, occurs mainly due to variants in SLC22A12 or SLC2A9. ...CONCLUSION: The current study reported six novel variants …
BACKGROUND: Renal hypouricemia (RHUC), a rare inherited disorder characterized by impaired uric acid reabsorption and subsequent prof …
Effect of Renal Impairment on the Pharmacokinetics and Pharmacodynamics of Verinurad, a Selective Uric Acid Reabsorption Inhibitor.
Smith WB, Hall J, Berg JK, Kazimir M, Yamamoto A, Walker S, Lee CA, Shen Z, Wilson DM, Zhou D, Gillen M, Marbury TC. Smith WB, et al. Clin Drug Investig. 2018 Aug;38(8):703-713. doi: 10.1007/s40261-018-0652-2. Clin Drug Investig. 2018. PMID: 29949102 Free PMC article. Clinical Trial.
CONCLUSION: Exposures of verinurad and metabolites increased with decreasing renal function. Consistent with the renal-dependent mechanism of action of verinurad, increasing severity of renal impairment was associated with decreased sUA lowering. Verinurad sa …
CONCLUSION: Exposures of verinurad and metabolites increased with decreasing renal function. Consistent with the renal-depende …
GLUT9 as a potential drug target for chronic kidney disease: Drug target validation by a Mendelian randomization study.
Ueda M, Fukui K, Kamatani N, Kamitsuji S, Matsuo A, Sasase T, Nishiu J, Matsushita M. Ueda M, et al. J Hum Genet. 2023 Oct;68(10):699-704. doi: 10.1038/s10038-023-01168-8. Epub 2023 Jun 13. J Hum Genet. 2023. PMID: 37308567
We focused on five uric acid transporters (ABCG2, SLC17A1, SLC22A11, SLC22A12, SLC2A9) as potential drug targets and evaluated the causal association between serum UA levels and estimated glomerular filtration rate (eGFR) using single-SNP Mendelian Randomization. ...These …
We focused on five uric acid transporters (ABCG2, SLC17A1, SLC22A11, SLC22A12, SLC2A9) as potential drug targets and evaluated the ca …
Non-urate transporter 1, non-glucose transporter member 9-related renal hypouricemia and acute renal failure accompanied by hyperbilirubinemia after anaerobic exercise: a case report.
Furuto Y, Kawamura M, Namikawa A, Takahashi H, Shibuya Y, Mori T, Sohara E. Furuto Y, et al. BMC Nephrol. 2019 Nov 26;20(1):433. doi: 10.1186/s12882-019-1618-1. BMC Nephrol. 2019. PMID: 31771519 Free PMC article.
BACKGROUND: Renal hypouricemia (RHUC) is an inherited heterogenous disorder caused by faulty urate reabsorption transporters in the renal proximal tubular cells. ...We detected acute kidney injury, with a creatinine (Cr) level of 4.1 mg/dL, and elevated bilirubin; h …
BACKGROUND: Renal hypouricemia (RHUC) is an inherited heterogenous disorder caused by faulty urate reabsorption transporters in the …
A heterozygous variant in the SLC22A12 gene in a Sri Lanka family associated with mild renal hypouricemia.
Vidanapathirana DM, Jayasena S, Jasinge E, Stiburkova B. Vidanapathirana DM, et al. BMC Pediatr. 2018 Jun 29;18(1):210. doi: 10.1186/s12887-018-1185-9. BMC Pediatr. 2018. PMID: 29958533 Free PMC article.
BACKGROUND: Renal hypouricemia is a rare heterogeneous inherited disorder characterized by impaired tubular uric acid transport, reabsorption insufficiency and /or acceleration of secretion. ...CASE PRESENTATION: Herein, we report a nine year old Sri Lankan boy with …
BACKGROUND: Renal hypouricemia is a rare heterogeneous inherited disorder characterized by impaired tubular uric acid transport, reab …
Non-urate transporter 1-related renal hypouricemia and acute renal failure in an Israeli-Arab family.
Bahat H, Dinour D, Ganon L, Feldman L, Holtzman EJ, Goldman M. Bahat H, et al. Pediatr Nephrol. 2009 May;24(5):999-1003. doi: 10.1007/s00467-008-1093-6. Epub 2009 Feb 3. Pediatr Nephrol. 2009. PMID: 19189137
Idiopathic renal hypouricemia (IRHU) is a rare hereditary disease, predisposing the individual to exercise-induced acute renal failure (EIARF) and nephrolithiasis, and it is characterized by increased clearance of renal uric acid. Most of the described patien …
Idiopathic renal hypouricemia (IRHU) is a rare hereditary disease, predisposing the individual to exercise-induced acute renal …
Recurrent exercise-induced acute renal failure in a young Pakistani man with severe renal hypouricemia and SLC2A9 compound heterozygosity.
Jeannin G, Chiarelli N, Gaggiotti M, Ritelli M, Maiorca P, Quinzani S, Verzeletti F, Possenti S, Colombi M, Cancarini G. Jeannin G, et al. BMC Med Genet. 2014 Jan 7;15:3. doi: 10.1186/1471-2350-15-3. BMC Med Genet. 2014. PMID: 24397858 Free PMC article.
BACKGROUND: Familial renal hypouricemia (RHUC) is a hereditary disease characterized by hypouricemia, high renal fractional excretion of uric acid (FE-UA) and can be complicated by acute kidney failure and nephrolithiasis. Loss-of-function mutations in the SLC22A …
BACKGROUND: Familial renal hypouricemia (RHUC) is a hereditary disease characterized by hypouricemia, high renal fractional ex …
Time to Target Uric Acid to Retard Chronic Kidney Disease Progression.
Uchida S, Kumagai T, Chang WX, Tamura Y, Shibata S. Uchida S, et al. Contrib Nephrol. 2018;192:56-68. doi: 10.1159/000484279. Epub 2018 Jan 23. Contrib Nephrol. 2018. PMID: 29393121 Review.
Our recent analysis by propensity score analysis has shown that the serum UA should be targeted below 6.0 mg/dL to inhibit the progression towards end-stage renal disease. Underlying mechanisms whereby an increase in serum UA induces kidney injury have been elucidated in a …
Our recent analysis by propensity score analysis has shown that the serum UA should be targeted below 6.0 mg/dL to inhibit the progression t …
52 results